院長 研究論文

1.Humoral immunity against the proline-rich peptide epitope of the IgA1 hinge region in IgA nephropathy.
Kokubo T, Hashizume K, Iwase H, Arai K, Tanaka A, Toma K, Hotta K, Kobayashi Y.
Nephrol Dial Transplant. 2000 Jan;15(1):28-33.

2. Exposed peptide core of IgA1 hinge region in IgA nephropathy.
Kokubo T, Hiki Y, Iwase H, Tanaka A, Nishikido J, Hotta K, Kobayashi Y.
Nephrol Dial Transplant. 1999 Jan;14(1):81-5.

3. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.
Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y.
J Am Soc Nephrol. 1998 Nov;9(11):2048-54.
 
4. Evidence for involvement of IgA1 hinge glycopeptide in the IgA1- IgA1 interaction in IgA nephropathy.
Kokubo T, Hiki Y, Iwase H, Horii A, Tanaka A, Nishikido J, Hotta K, Kobayashi Y.
J Am Soc Nephrol. 1997 Jun;8(6):915-9.

5. Enzymatically deglycosylated human IgA1 molecules accumulate and induce inflammatory cell reaction in rat glomeruli.
Sano T, Hiki Y, Kokubo T, Iwase H, Shigematsu H, Kobayashi Y.
Nephrol Dial Transplant. 2002 Jan;17(1):50-6.

6. Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy.
Hiki Y, Kokubo T, Iwase H, Masaki Y, Sano T, Tanaka A, Toma K, Hotta K, Kobayashi Y.
J Am Soc Nephrol. 1999 Apr;10(4):760-9.

7. Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix- assisted laser desorption/ionization time-of-flight mass spectrometry.
Hiki Y, Tanaka A, Kokubo T, Iwase H, Nishikido J, Hotta K, Kobayashi Y.
J Am Soc Nephrol. 1998 Apr;9(4):577-82.

8. Association of asialo-galactosyl beta 1-3N-acetylgalactosamine on the hinge with a conformational instability of Jacalin- reactive immunoglobulin A1 in immunoglobulin A nephropathy.
Hiki Y, Iwase H, Kokubo T, Horii A, Tanaka A, Nishikido J, Hotta K, Kobayashi Y.
J Am Soc Nephrol. 1996 Jun;7(6):955-60.

9. Detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients by using synthetic hinge peptide and glycopeptide probes.
Nakamura I, Iwase H, Arai K, Nagai Y, Toma K, Katsumata T, Hiki Y, Kokubo T, Sano T, Kobayashi Y.
Nephrology (Carlton). 2004 Feb;9(1):26-30.

10. Human serum immunoglobulin G3 subclass bound preferentially to asialo-, agalactoimmunoglobulin A1/Sepharose.
Iwase H, Yokozeki Y, Hiki Y, Tanaka A, Kokubo T, Sano T, Ishii-
Karakasa I, Hisatani K, Kobayashi Y, Hotta K.
Biochem Biophys Res Commun. 1999 Oct 22;264(2):424-9.

11. Analysis of the microheterogeneity of the IgA1 hinge glycopeptide having multiple O-linked oligosaccharides by capillary electrophoresis.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Sano T, Ishii-Karakasa I, Hisatani K, Kobayashi Y, Hotta K.
Anal Biochem. 2001 Jan 1;288(1):22-7.

12. Study of the relationship between sticky human serum IgA1 and its O-glycan glycoform.
Iwase H, Ohkawa S, Ishii-Karakasa I, Hiki Y, Kokubo T, Sano T, Tanaka A, Toma K, Kobayashi Y, Hotta K.
Biochem Biophys Res Commun. 1999 Aug 2;261(2):472-7.

13. Mutual separation of hinge-glycopeptide isomers bearing five N- acetylgalactosamine residues from normal human serum immunoglobulin A1 by capillary electrophoresis.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Sano T, Ishii-Karakasa I, Toma K, Kobayashi Y, Hotta K.
J Chromatogr B Biomed Sci Appl. 1999 May 28;728(2):175-83.


14. Evidence for a site-specific fucosylation of N-linked oligosaccharide of immunoglobulin A1 from normal human serum.
Tanaka A, Iwase H, Hiki Y, Kokubo T, Ishii-Karakasa I, Toma K, Kobayashi Y, Hotta K.
Glycoconj J. 1998 Oct;15(10):995-1000.

15. Aggregated human serum immunoglobulin A1 induced by neuraminidase treatment had a lower number of O-linked sugar chains on the hinge portion.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Sano T, Ishii-Karakasa I, Toma K, Kobayashi Y, Hotta K.
J Chromatogr B Biomed Sci Appl. 1999 Mar 5;724(1):1-7.

16. Application of matrix-assisted laser desorption ionization time-of- flight mass spectrometry to the analysis of glycopeptide-containing multiple O-linked oligosaccharides.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Ishii-Karakasa I, Nishikido J, Kobayashi Y, Hotta K.
J Chromatogr B Biomed Sci Appl. 1998 May 8;709(1):145-9.
 
17. Estimation of the number of O-linked oligosaccharides per heavy chain of human serum IgA1 by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) analysis of the hinge glycopeptide.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Ishii-Karakasa I, Kobayashi Y, Hotta K.
J Biochem. 1996 Aug;120(2):393-7.

18. Abundance of Gal beta 1,3GalNAc in O-linked oligosaccharide on hinge region of polymerized IgA1 and heat-aggregated IgA1 from normal human serum.
Iwase H, Tanaka A, Hiki Y, Kokubo T, Ishii-Karakasa I, Kobayashi Y, Hotta K.
J Biochem. 1996 Jul;120(1):92-7.

19. Steroid therapy during the early stage of progressive IgA nephropathy. A 10-year follow-up study.
Kobayashi Y, Hiki Y, Kokubo T, Horii A, Tateno S.
Nephron. 1996;72(2):237-42.
 
20. Lipoprotein derangement during steroid treatment in minimal-change nephrotic syndrome.
Tsukamoto Y, Kokubo T, Horii A, Moriya R, Kobayashi Y.
Nephron. 1996;73(4):606-12.

21. A case of rheumatoid arthritis with renal tubular amyloidosis.
Hiki Y, Horii A, Kokubo T, Ishikawa S, Sugiyama T, Shigematsu H, Kobayashi Y.
Nephron. 1994;68(3):394-5. No abstract available.

22. Prognostic significance of persistent massive proteinuria in progressive IgA nephropathy–a long-term follow-up study.
Kokubo T, Hiki Y, Tateno S, Kobayashi Y.
Nihon Jinzo Gakkai Shi. 1994 Jul;36(7):823-31. Japanese.

23. A case of severe IgA nephropathy associated with psoriatic arthritis and idiopathic interstitial pneumonia.
Hiki Y, Kokubo T, Horii A, Yokouchi S, Satoh M, Kuwao S, Shigematsu H, Kobayashi Y.
Acta Pathol Jpn. 1993 Sep;43(9):522-8.

24. Recklinghausen’s neurofibromatosis associated with membranous nephropathy.
Kokubo T, Hiki Y, Horii A, Kobayashi Y.
Nephron. 1993;65(3):486.

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